You can lose the sense of reality by playing the game a lot. Or doing any activity for that matter. If you would work 100 hours a week, every week, you could lose your sense of reality.
Consider checking the mental health reports on people working 16 hours a day. It was shockingly common in 19th century Europe for women to kill their young children, or let them simply die of neglect. They simply could not care about them.
It seems likely that whatever it is that is occupying you so completely, will have an effect on what the person who is engaging in behavior is going to do.
But of course the game should not be blamed.
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